Rovenská Eva
Vnitr Lek. 2014 Jul-Aug;60(7-8):582-5.
Lymphangiogenesis - proliferation of lymphatic capillaries - in melanoma and in its vicinity plays an important role in metastatic process of malign melanoma cells in organism. Melanoma produces epidermal growth factor EGF which induces vascular endothelial growth factor VEGF-C and thereby starts lymphangiogenesis. It is very probable that malignant melanoma cells enter lymphatic capillaries also through specialized inter-endothelial junctions (endothelial microvalves, primary valves) situated in their walls. After entry of malign cells into lymphatic capillaries, these cells travel in lymph to the sentinel lymph node. Malign cells metastasize through lymphatic vessels probably also directly into distal regional lymphatic nodes. Metastasizing through blood vessels is suggestible also in early stage melanoma.
淋巴管生成——淋巴管的增殖——在黑色素瘤及其周边区域，在恶性黑色素瘤细胞在机体中的转移过程中发挥着重要作用。黑色素瘤产生表皮生长因子（EGF），其诱导血管内皮生长因子（VEGF-C），从而启动淋巴管生成。恶性黑色素瘤细胞很可能也通过位于其壁上的特殊内皮间连接（内皮微瓣膜、初级瓣膜）进入淋巴管。恶性细胞进入淋巴管后，这些细胞随淋巴液流向前哨淋巴结。恶性细胞可能也通过淋巴管直接转移至远处区域淋巴结。在黑色素瘤早期，通过血管转移也是有可能的。
