Albiser G, Harmouchi M, Premilat S
Laboratoire de Biophysique moléculaire, U.A. C.N.R.S. n. 494, Université de Nancy-I, Faculté des Sciences, Vandoeuvre-lès-Nancy.
C R Acad Sci III. 1989;309(15):611-6.
An experimental method combining fiber X-ray and direct fiber dimension measurements is proposed for the study of DNA conformational transitions. Curves corresponding to the A-B and B-C transitions are obtained by using the proportionality which exists between the fiber length and the axial rise per nucleotide in the DNA helix. The A-B transition is shown to be cooperative while the B-C one is a progressive change of helical conformation.
提出了一种结合纤维X射线和直接纤维尺寸测量的实验方法来研究DNA构象转变。通过利用DNA螺旋中纤维长度与每核苷酸轴向上升之间存在的比例关系，获得了对应于A - B和B - C转变的曲线。结果表明，A - B转变是协同的，而B - C转变是螺旋构象的渐进变化。
