新生儿护理：积极与消极影响概述
Neonatal handling: an overview of the positive and negative effects.
作者信息
Raineki Charlis, Lucion Aldo B, Weinberg Joanne
机构信息
Department of Cellular and Physiological Sciences, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada, V6T 1Z3.
出版信息
Dev Psychobiol. 2014 Dec;56(8):1613-25. doi: 10.1002/dev.21241. Epub 2014 Aug 4.
Abstract
As one of the first rodent models designed to investigate the effects of early-life experiences, the neonatal handling paradigm has helped us better understand how subtle changes in the infant environment can powerfully drive neurodevelopment of the immature brain in typical or atypical trajectories. Here, we review data from more than 50 years demonstrating the compelling effects of neonatal handling on behavior, physiology, and neural function across the lifespan. Moreover, we present data that challenge the classical view of neonatal handling as an animal model that results only in positive/beneficial outcomes. Indeed, the overall goal of this review is to offer the suggestion that the effects of early-life experiences-including neonatal handling-are nuanced rather than unidirectional. Both beneficial and negative outcomes may occur, depending on the parameters of testing, sex of the subject, and neurobehavioral system analyzed.
摘要
作为最早设计用于研究早期生活经历影响的啮齿动物模型之一，新生儿抚触范式帮助我们更好地理解婴儿环境中的细微变化如何有力地推动未成熟大脑在典型或非典型轨迹上的神经发育。在此，我们回顾了50多年来的数据，这些数据表明新生儿抚触对整个生命周期的行为、生理和神经功能具有令人信服的影响。此外，我们还展示了一些数据，这些数据挑战了将新生儿抚触视为仅产生积极/有益结果的动物模型的经典观点。事实上，本综述的总体目标是提出这样的建议，即早期生活经历（包括新生儿抚触）的影响是细微的，而不是单向的。根据测试参数、受试者性别和所分析的神经行为系统的不同，可能会出现有益和负面的结果。
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