新生儿护理：积极与消极影响概述
Neonatal handling: an overview of the positive and negative effects.
作者信息
Raineki Charlis, Lucion Aldo B, Weinberg Joanne
机构信息
Department of Cellular and Physiological Sciences, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada, V6T 1Z3.
出版信息
Dev Psychobiol. 2014 Dec;56(8):1613-25. doi: 10.1002/dev.21241. Epub 2014 Aug 4.
Abstract
As one of the first rodent models designed to investigate the effects of early-life experiences, the neonatal handling paradigm has helped us better understand how subtle changes in the infant environment can powerfully drive neurodevelopment of the immature brain in typical or atypical trajectories. Here, we review data from more than 50 years demonstrating the compelling effects of neonatal handling on behavior, physiology, and neural function across the lifespan. Moreover, we present data that challenge the classical view of neonatal handling as an animal model that results only in positive/beneficial outcomes. Indeed, the overall goal of this review is to offer the suggestion that the effects of early-life experiences-including neonatal handling-are nuanced rather than unidirectional. Both beneficial and negative outcomes may occur, depending on the parameters of testing, sex of the subject, and neurobehavioral system analyzed.
摘要
作为最早设计用于研究早期生活经历影响的啮齿动物模型之一，新生儿抚触范式帮助我们更好地理解婴儿环境中的细微变化如何有力地推动未成熟大脑在典型或非典型轨迹上的神经发育。在此，我们回顾了50多年来的数据，这些数据表明新生儿抚触对整个生命周期的行为、生理和神经功能具有令人信服的影响。此外，我们还展示了一些数据，这些数据挑战了将新生儿抚触视为仅产生积极/有益结果的动物模型的经典观点。事实上，本综述的总体目标是提出这样的建议，即早期生活经历（包括新生儿抚触）的影响是细微的，而不是单向的。根据测试参数、受试者性别和所分析的神经行为系统的不同，可能会出现有益和负面的结果。
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本文引用的文献
1
Neural control of chronic stress adaptation.
Front Behav Neurosci. 2013 Aug 8;7:61. doi: 10.3389/fnbeh.2013.00061. eCollection 2013.
2
Enriched early life experiences reduce adult anxiety-like behavior in rats: a role for insulin-like growth factor 1.
J Neurosci. 2013 Jul 10;33(28):11715-23. doi: 10.1523/JNEUROSCI.3541-12.2013.
3
Early life manipulations alter learning and memory in rats.
Neurosci Biobehav Rev. 2012 Oct;36(9):1985-2006. doi: 10.1016/j.neubiorev.2012.07.003. Epub 2012 Jul 20.
4
Effects of early-life abuse differ across development: infant social behavior deficits are followed by adolescent depressive-like behaviors mediated by the amygdala.
J Neurosci. 2012 May 30;32(22):7758-65. doi: 10.1523/JNEUROSCI.5843-11.2012.
5
Neonatal handling induces deficits in infant mother preference and adult partner preference.
Dev Psychobiol. 2013 Jul;55(5):496-507. doi: 10.1002/dev.21053. Epub 2012 May 29.
6
Social influences on neuroplasticity: stress and interventions to promote well-being.
Nat Neurosci. 2012 Apr 15;15(5):689-95. doi: 10.1038/nn.3093.
7
Neural Regulation of the Stress Response: The Many Faces of Feedback.
Cell Mol Neurobiol. 2012 Feb 1;32(5):683-94. doi: 10.1007/s10571-012-9801-y.
8
Toward understanding how early-life social experiences alter oxytocin- and vasopressin-regulated social behaviors.
Horm Behav. 2012 Mar;61(3):304-12. doi: 10.1016/j.yhbeh.2011.12.002. Epub 2011 Dec 14.
9
Evaluation of the brain and kidney renin-angiotensin system and oxidative stress in neonatal handled rats.
Dev Psychobiol. 2012 Nov;54(7):706-13. doi: 10.1002/dev.20620. Epub 2011 Nov 29.
10
Current research trends in early life stress and depression: review of human studies on sensitive periods, gene-environment interactions, and epigenetics.
Exp Neurol. 2012 Jan;233(1):102-11. doi: 10.1016/j.expneurol.2011.10.032. Epub 2011 Nov 7.
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