美国社区获得性产超广谱β-内酰胺酶大肠杆菌菌株的分子特征
Molecular features of community-associated extended-spectrum-β-lactamase-producing Escherichia coli strains in the United States.
作者信息
Hu Fupin, O'Hara Jessica A, Rivera Jesabel I, Doi Yohei
机构信息
Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, China.
Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
出版信息
Antimicrob Agents Chemother. 2014 Nov;58(11):6953-7. doi: 10.1128/AAC.03321-14. Epub 2014 Aug 18.
Abstract
We characterized 30 community-associated extended-spectrum-β-lactamase-producing Escherichia coli isolates collected from five hospitals in the United States. Nineteen sequence types were identified. All sequence type 131 (ST131) isolates had the fimH30 allele. IncFII-FIA-FIB was the most common replicon type among the blaCTX-M-carrying plasmids, followed by IncFII-FIA and IncA/C. Restriction analysis of the IncFII-FIA-FIB and IncFII-FIA plasmids yielded related profiles for plasmids originating from different hospitals. The plasmids containing blaCTX-M or blaSHV were stably maintained after serial passages.
摘要
我们对从美国五家医院收集的30株产社区获得性超广谱β-内酰胺酶的大肠杆菌分离株进行了特征分析。鉴定出了19种序列类型。所有序列类型131（ST131）分离株均具有fimH30等位基因。IncFII-FIA-FIB是携带blaCTX-M质粒中最常见的复制子类型，其次是IncFII-FIA和IncA/C。对IncFII-FIA-FIB和IncFII-FIA质粒的限制性分析得出了来自不同医院的质粒的相关图谱。含有blaCTX-M或blaSHV的质粒在连续传代后能稳定维持。
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