c-Myc与AP4：CD8+T细胞代谢重编程的接力团队。 - Suppr

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c-Myc and AP4: a relay team for metabolic reprogramming of CD8+ T cells.

作者信息

Karmaus Peer W F, Chi Hongbo

机构信息

Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

出版信息

Nat Immunol. 2014 Sep;15(9):828-9. doi: 10.1038/ni.2962.

DOI:10.1038/ni.2962

PMID:25137465

Abstract

摘要

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c-Myc-induced transcription factor AP4 is required for host protection mediated by CD8+ T cells.

Nat Immunol. 2014 Sep;15(9):884-93. doi: 10.1038/ni.2943. Epub 2014 Jul 13.

GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling.

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J Exp Med. 2015 Aug 24;212(9):1345-60. doi: 10.1084/jem.20151159. Epub 2015 Aug 10.

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c-Myc-induced transcription factor AP4 is required for host protection mediated by CD8+ T cells.

Nat Immunol. 2014 Sep;15(9):884-93. doi: 10.1038/ni.2943. Epub 2014 Jul 13.

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Immunity. 2013 Dec 12;39(6):1043-56. doi: 10.1016/j.immuni.2013.09.015. Epub 2013 Dec 5.

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Science. 2013 Oct 11;342(6155):1242454. doi: 10.1126/science.1242454.

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation.

Nat Immunol. 2013 May;14(5):500-8. doi: 10.1038/ni.2556. Epub 2013 Mar 24.

c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells.

Cell. 2012 Sep 28;151(1):68-79. doi: 10.1016/j.cell.2012.08.033.

Regulation and function of mTOR signalling in T cell fate decisions.

Nat Rev Immunol. 2012 Apr 20;12(5):325-38. doi: 10.1038/nri3198.

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation.

Immunity. 2011 Dec 23;35(6):871-82. doi: 10.1016/j.immuni.2011.09.021.

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The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin.

Immunity. 2010 Jan 29;32(1):67-78. doi: 10.1016/j.immuni.2009.10.010. Epub 2010 Jan 7.

mTOR regulates memory CD8 T-cell differentiation.

Nature. 2009 Jul 2;460(7251):108-12. doi: 10.1038/nature08155. Epub 2009 Jun 21.