Welsh Raymond M
Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Immunity. 2009 Aug 21;31(2):178-80. doi: 10.1016/j.immuni.2009.08.005.
The functions of T lymphocytes are regulated by transcription factors controlling gene expression. Three studies in this issue of Immunity (Kallies et al., 2009; Rutishauser et al., 2009; Shin et al., 2009) indicate that the transcriptional repressor Blimp-1 promotes the development of short-lived effector cells and regulates clonal exhaustion.
T淋巴细胞的功能受控制基因表达的转录因子调节。本期《免疫》杂志上的三项研究(Kallies等人,2009年;Rutishauser等人,2009年;Shin等人,2009年)表明,转录抑制因子Blimp-1促进短命效应细胞的发育并调节克隆耗竭。