芬兰北部的孕早期联合筛查：头十年的经验
Combined first-trimester screening in northern Finland: experiences of the first ten years.
作者信息
Merilainen Anna, Peuhkurinen Sini, Honkasalo Timppa, Laitinen Paivi, Kokkonen Hannaleena, Ryynanen Markku, Marttala Jaana
机构信息
Department of Obstetrics and Gynecology, Oulu University Hospital, Finland.
Clinical Chemistry and Hematology, Helsinki University Hospital, Finland.
出版信息
Clin Med Insights Reprod Health. 2014 Jul 30;8:45-9. doi: 10.4137/CMRH.S14958. eCollection 2014.
OBJECTIVE
To evaluate the efficacy of first trimester combined screening for Down's syndrome in Northern Finland during the first 10 years of practice.
METHODS
During 1 January 2002 to 31 December 2011, 47,896 women participated voluntarily in combined screening during first trimester. The risk cutoff was 1:250. The study period was divided into two time periods; 2002-2006 and 2007-2011.
RESULTS
During the first half of the study period, the detection rate (DR) was 77.3% with a 4.9% false-positive rate (FPR). During the latter half, the DR was 77.1% with a 2.8% FPR.
CONCLUSIONS
An important issue is the number of invasive procedures needed to detect one case of Down's syndrome. The screening performance improved markedly in the latter five years period since the FPR lowered from 4.9% to 2.8% and the number of invasive procedures needed to detect one case of Down's syndrome lowered from 15 to 11.
目的
评估芬兰北部孕早期唐氏综合征联合筛查在实施的头10年中的效果。
方法
在2002年1月1日至2011年12月31日期间，47,896名妇女在孕早期自愿参加了联合筛查。风险截断值为1:250。研究期分为两个时间段；2002 - 2006年和2007 - 2011年。
结果
在研究期的前半段，检出率（DR）为77.3%，假阳性率（FPR）为4.9%。在后半段，DR为77.1%，FPR为2.8%。
结论
一个重要问题是检测出一例唐氏综合征所需的侵入性检查数量。在最近五年期间筛查性能显著改善，因为FPR从4.9%降至2.8%，且检测出一例唐氏综合征所需的侵入性检查数量从15次降至11次。
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