Department of Child Health, Netherlands Organization for Applied Scientific Research, TNO, Leiden, The Netherlands.
Prenat Diagn. 2012 Nov;32(11):1035-40. doi: 10.1002/pd.3951. Epub 2012 Aug 6.
This study aims to evaluate trends in prevalence of Down syndrome (DS) births in the Netherlands over an 11-year period and how they have been affected by maternal age and introduction of prenatal screening.
Nationwide data of an 11-year birth cohort (1997-2007) from the Netherlands Perinatal Registry were analyzed. First-trimester combined screening was introduced in 2002, free of charge only for women 36 years of age or older and only on patients' request. Changes in maternal age, prevalence of DS births, and rates of births at <24 weeks (legal limit for termination of pregnancy in the Netherlands) during the study period were evaluated using logistic and linear regression analyses.
In total, 1,972,058 births were registered (91% of the births in 1997-2007). Mean prevalence of DS was 14.57 per 10,000 births (95% confidence interval 14.43; 14.73); 85% of DS were live births. No significant trend in overall prevalence of DS births was observed (p = 0.385), in spite of a significant increase of mean maternal age during the same period (p < 0.001). The increased prevalence of DS births at ≥ 24 weeks among women ≥ 36 years of age (p = 0.011) was offset by a significant increase in the proportion of DS births at <24 weeks among women aged <36 years (p = 0.013).
The proportion of DS births in the Netherlands has not changed during the period 1997-2007.
本研究旨在评估荷兰 11 年间唐氏综合征（DS）出生率的趋势，以及其受孕妇年龄和产前筛查引入的影响。
对荷兰围产期登记处的 11 年出生队列（1997-2007 年）的全国性数据进行了分析。2002 年引入了早孕期联合筛查，仅对年龄在 36 岁及以上的妇女免费提供，且仅应患者要求提供。使用逻辑回归和线性回归分析评估研究期间孕妇年龄、DS 出生率以及 <24 周出生（荷兰终止妊娠的合法限制）的发生率变化。
共登记了 1972058 例分娩（占 1997-2007 年分娩的 91%）。DS 的平均发病率为每 10000 例活产 14.57 例（95%置信区间 14.43；14.73）；85%的 DS 为活产儿。尽管同期孕妇平均年龄显著增加（p<0.001），但总体 DS 出生率未见显著趋势（p=0.385）。≥36 岁孕妇的 ≥24 周 DS 出生率增加（p=0.011），但<36 岁孕妇的 <24 周 DS 出生率显著增加（p=0.013），抵消了这一趋势。
1997-2007 年间，荷兰的 DS 出生率比例没有变化。
