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Studies on aldose reductase inhibitors from natural products. II. Active components of a Paraguayan crude drug "Para-parai mí," Phyllanthus niruri.

作者信息

Shimizu M, Horie S, Terashima S, Ueno H, Hayashi T, Arisawa M, Suzuki S, Yoshizaki M, Morita N

出版信息

Chem Pharm Bull (Tokyo). 1989 Sep;37(9):2531-2. doi: 10.1248/cpb.37.2531.

DOI:10.1248/cpb.37.2531
PMID:2514047
Abstract

Aldose reductase (AR) inhibitory activity-directed fractionation of the 70% ethanolic extract of Para-parai mí, Phyllanthus niruri, has led to the isolation of three active components, ellagic acid (1), brevifolin carboxylic acid (4) and ethyl brevifolin carboxylate (5). Among them, 1 showed the highest inhibitory activity, being about 6 times more potent than quercitrin, which is a known natural inhibitor of AR.

摘要

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