斑块型银屑病中环孢素与阿维A治疗下白细胞介素-2和肿瘤坏死因子-α的血清浓度
Serum concentrations of interleukin-2 and tumour necrosis factor-α under cyclosporine versus acitretin treatment in plaque-type psoriasis.
作者信息
Akçali Cenk, Guven Ebru Homurlu, Kirtak Necmettin, Inaloz H Serhat, Ozgoztasi Orhan, Guvenc Ulas
机构信息
Department of Dermatology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey
Department of Dermatology, Avukat Cengiz Gokcek State Hospital, Gaziantep, Turkey.
出版信息
J Int Med Res. 2014 Oct;42(5):1118-22. doi: 10.1177/0300060514539280. Epub 2014 Aug 20.
OBJECTIVE
A prospective, randomized clinical study to compare the short-term effects of cyclosporin and acitretin on psoriasis severity, and serum interleukin (IL)-2 and tumour necrosis factor (TNF)-α concentrations.
METHODS
Patients with moderate-to-severe plaque-type psoriasis were randomly assigned to receive either 3 mg/kg per day cyclosporine or 0.3-0.5 mg/kg per day acitretin for 8 weeks. Disease severity (psoriasis area severity index [PASI] score) and serum IL-2 and TNF-α concentrations were determined before and after treatment.
RESULTS
PASI scores and serum IL-2 and TNF-α concentrations were significantly decreased after treatment with either cyclosporine (n = 21) or acitretin (n = 25). There were no statistically significant between-group differences in any parameter.
CONCLUSIONS
Acitretin and cyclosporine are equally effective in the treatment of moderate-to-severe plaque-type psoriasis.
目的
一项前瞻性随机临床研究，比较环孢素和阿维A对银屑病严重程度以及血清白细胞介素（IL）-2和肿瘤坏死因子（TNF）-α浓度的短期影响。
方法
中重度斑块型银屑病患者被随机分配，接受每日3mg/kg环孢素或每日0.3 - 0.5mg/kg阿维A治疗8周。在治疗前后测定疾病严重程度（银屑病面积严重指数[PASI]评分）以及血清IL-2和TNF-α浓度。
结果
环孢素组（n = 21）和阿维A组（n = 25）治疗后PASI评分以及血清IL-2和TNF-α浓度均显著降低。各参数在组间均无统计学显著差异。
结论
阿维A和环孢素在治疗中重度斑块型银屑病方面同样有效。
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