Krvavica Ana, Morović Miro, Mrden Anamarija, Mislov Damir, Duka-Glavor Klaudia, Ivanac Kresimir, Gelpi Ellen
Coll Antropol. 2014 Jun;38(2):701-4.
The objective of this work is to describe the neuropathological findings of a patient clinically presenting with rapidly progressive nonspecific neurological symptoms suggestive of Creutzfeldt-Jakob disease. Methods used were clinical description with laboratory analyses, repeated electroencephalogram, cerebral computed tomography, magnetic resonance imaging studies and details on neuropathological work-up. Neuropathological examination excluded Creutzfeldt-Jakob disease. By contrast other neurodegenerative changes combining Alzheimer-type pathology and Lewy body pathology were detected as the most likely substrate of neurological symptoms. Dementia with Lewy bodies should be included in the differential diagnosis in individuals presenting with rapidly progressive dementia.
这项工作的目的是描述一名临床上表现出快速进展的非特异性神经症状、提示克雅氏病的患者的神经病理学发现。所采用的方法包括临床描述及实验室分析、多次脑电图检查、脑部计算机断层扫描、磁共振成像研究以及神经病理学检查的详细情况。神经病理学检查排除了克雅氏病。相比之下，检测到其他结合了阿尔茨海默型病理学和路易体病理学的神经退行性变化，这是最有可能导致神经症状的基础。路易体痴呆应纳入快速进展性痴呆患者的鉴别诊断中。
