铜绿假单胞菌疫苗保护效力的实验研究
Experimental studies on the protective efficacy of a Pseudomonas aeruginosa vaccine.
作者信息
Stanislavsky E S, Edvabnaya L S, Bandman O A, Boolk V F, Zhvanetskaya M I, Vargina A K
机构信息
I.I. Mechnikov Central Research Institute of Vaccines and Sera, Moscow,USSR.
出版信息
Vaccine. 1989 Dec;7(6):562-6. doi: 10.1016/0264-410x(89)90284-3.
Pseudomonas aeruginosa vaccine (PV) containing cell proteins with molecular weight (Mr) 20,000-100,000 and up to 0.08% (w/v) admixture of lipopolysaccharide was obtained by water-salt extraction and subsequent ultrafiltration. PV protects mice against experimental P. aeruginosa infection, stimulates production of specific protective antibodies in rabbit and does not provoke obvious toxicity in laboratory animals.
通过水盐萃取和随后的超滤获得了含有分子量（Mr）为20,000 - 100,000的细胞蛋白以及高达0.08%（w/v）脂多糖混合物的铜绿假单胞菌疫苗（PV）。PV可保护小鼠免受实验性铜绿假单胞菌感染，刺激兔子产生特异性保护性抗体，并且在实验动物中不会引发明显毒性。
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