儿童恶性肿瘤的免疫治疗：现状与未来展望。
Immunotherapy in pediatric malignancies: current status and future perspectives.
作者信息
Capitini Christian M, Otto Mario, DeSantes Kenneth B, Sondel Paul M
机构信息
Department of Pediatrics & Carbone Cancer Center, University of Wisconsin School of Medicine & Public Health, 1111 Highland Avenue, WIMR 4137, Madison, WI 53705, USA.
出版信息
Future Oncol. 2014;10(9):1659-78. doi: 10.2217/fon.14.62.
Novel immune-based therapies are becoming available as additions to, and in some cases as alternatives to, the traditional treatment modalities such as chemotherapy, surgery and radiation that have improved outcomes for childhood cancer for decades. In this article, we will discuss what immunotherapies are being tested in the clinic, barriers to widespread application, and the future of immuno-oncology for childhood cancer. While in many cases, these therapies have shown dramatic responses in the setting of refractory or relapsed cancer, much remains to be learned about how to integrate these therapies into existing upfront regimens. The progress and challenges of developing immunotherapies for childhood cancer in a timely and cost-effective fashion will be discussed.
新型免疫疗法正作为传统治疗方式（如化疗、手术和放疗）的补充出现，在某些情况下还可替代这些传统治疗方式，而传统治疗方式数十年来已改善了儿童癌症的治疗效果。在本文中，我们将讨论哪些免疫疗法正在临床中进行测试、广泛应用的障碍以及儿童癌症免疫肿瘤学的未来。虽然在许多情况下，这些疗法在难治性或复发性癌症中已显示出显著疗效，但关于如何将这些疗法纳入现有的初始治疗方案仍有许多需要了解的地方。我们将讨论及时且经济高效地开发儿童癌症免疫疗法的进展和挑战。
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