药物与环肽-聚合物自组装纳米管的偶联。
Drug conjugation to cyclic peptide-polymer self-assembling nanotubes.
作者信息
Blunden Bianca M, Chapman Robert, Danial Maarten, Lu Hongxu, Jolliffe Katrina A, Perrier Sébastien, Stenzel Martina H
机构信息
Centre for Advanced Macromolecular Design, School of Chemistry, University of New South Wales, Sydney, NSW 2052 (Australia); Cooperative Research Centre (CRC) for Polymers, 8 Redwood Drive, Notting Hill, Victoria 3618 (Australia).
出版信息
Chemistry. 2014 Sep 26;20(40):12745-9. doi: 10.1002/chem.201403130. Epub 2014 Aug 21.
We show for the first time how polymeric nanotubes (NTs) based on self-assembled conjugates of polymers and cyclic peptides can be used as an efficient drug carrier. RAPTA-C, a ruthenium-based anticancer drug, was conjugated to a statistical co-polymer based on poly(2-hydroxyethyl acrylate) (pHEA) and poly(2-chloroethyl methacrylate) (pCEMA), which formed the shell of the NTs. Self-assembly into nanotubes (length 200-500 nm) led to structures exhibiting high activity against cancer cells.
我们首次展示了基于聚合物与环肽自组装共轭物的聚合物纳米管（NTs）如何用作高效药物载体。抗癌钌基药物RAPTA-C与基于聚（丙烯酸2-羟乙酯）（pHEA）和聚（甲基丙烯酸2-氯乙酯）（pCEMA）的统计共聚物共轭，该共聚物形成了纳米管的外壳。自组装成纳米管（长度为200 - 500纳米）后形成的结构对癌细胞表现出高活性。
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