Department of Biotechnology and Pharmaceutical Technology, Yuanpei University of Medical Technology, Hsinchu, Taiwan.
Department of Pharmaceutics, School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.
J Food Drug Anal. 2019 Jan;27(1):32-47. doi: 10.1016/j.jfda.2018.09.004. Epub 2018 Sep 28.
Self-assembled cyclic peptide nanotubes (cPNTs) have recently drawn particular attention as one of the most intriguing nanostructures in the field of nanotechnology. Given their unique features including high surface area, increased drug loading, environmental stability, enhanced permeation, and modifiable drug release, these hollow tubular structures can be constructed with cyclic di-, tri-, tetra-, hexa-, octa-, and decapeptides with various amino acid sequences, enantiomers, and functionalized side chains and can be applied for antiviral and antibacterial drugs, drug delivery and gene delivery vectors, organic electronic devices, and ionic or molecular channels. Recent publications have presented promising results regarding the use of cPNTs as drugs or biomedical devices. However, there is an urgent need for the further in vivo nanotoxicity and safety testing of these nanotubes to evaluate their suitability in different fields.
自组装环肽纳米管（cPNTs）作为纳米技术领域最引人关注的纳米结构之一，最近引起了特别关注。由于其具有独特的特性，包括高表面积、增加药物负载、环境稳定性、增强渗透和可调节的药物释放，这些空心管状结构可以由具有各种氨基酸序列、对映异构体和官能化侧链的环状二肽、三肽、四肽、六肽、八肽和十肽构建，并可应用于抗病毒和抗菌药物、药物输送和基因输送载体、有机电子设备以及离子或分子通道。最近的出版物提出了使用 cPNTs 作为药物或生物医学设备的有希望的结果。然而，迫切需要进一步对这些纳米管进行体内纳米毒性和安全性测试，以评估它们在不同领域的适用性。
