Bonne C, Muller A, Latour E, Tissie G, Emerit I, Modat G, Dornand J, Roch M, Giroud J P, Griswold D E
Centre de Recherches, Laboratoire Chauvin, Montpellier, France.
Arzneimittelforschung. 1989 Oct;39(10):1242-5.
2-(2-Hydroxy-4-methylphenyl)aminothiazole hydrochloride (CBS-113 A) inhibits cyclooxygenase in platelets and 5-lipoxygenase in leukocytes at micromolar concentrations. On the other hand the drug is a potent scavenger of oxygen-derived free radicals. Moreover and possibly consequently, CBS-113 A inhibits the oxygen burst of stimulated leukocytes and the release of an interleukin 1-like compound from vascular endothelial cells in culture. These properties could lead to another activity of therapeutic interest in comparison with anti-inflammatory drugs already available.
2-(2-羟基-4-甲基苯基)氨基噻唑盐酸盐（CBS-113 A）在微摩尔浓度下可抑制血小板中的环氧化酶和白细胞中的5-脂氧合酶。另一方面，该药物是氧衍生自由基的有效清除剂。此外，可能因此，CBS-113 A可抑制受刺激白细胞的氧爆发以及培养的血管内皮细胞中白细胞介素1样化合物的释放。与现有的抗炎药物相比，这些特性可能会引发另一种具有治疗意义的活性。
