（E）-2-苯并噻唑腙的合成与抗癌活性
Synthesis and anticancer activity of (E)-2-benzothiazole hydrazones.
作者信息
Lindgren Eric B, de Brito Monique A, Vasconcelos Thatyana R A, de Moraes Manuel O, Montenegro Raquel C, Yoneda Julliane D, Leal Kátia Z
机构信息
Programa de Pós-Graduação em Química, Instituto de Química, Universidade Federal Fluminense, Outeiro de São João Batista s/n°, 24020-141 Niterói, RJ, Brazil.
Faculdade de Farmácia, Universidade Federal Fluminense, Rua Mário Viana 523, 24241-000 Niterói, RJ, Brazil.
出版信息
Eur J Med Chem. 2014 Oct 30;86:12-6. doi: 10.1016/j.ejmech.2014.08.039. Epub 2014 Aug 11.
Benzothiazole hydrazones have been synthesized and evaluated for their in vitro antiproliferative activity against three human cancer cell lines: HL-60 (leukemia), MDAMB-435 (breast) and HCT-8 (colon). The good cytotoxicity for the three cancer cell lines and theoretical profile of compounds 3o and 3p pointed them as promising lead molecules for anticancer drug design.
苯并噻唑腙已被合成，并针对三种人类癌细胞系进行了体外抗增殖活性评估：HL-60（白血病）、MDA-MB-435（乳腺癌）和HCT-8（结肠癌）。化合物3o和3p对这三种癌细胞系具有良好的细胞毒性以及理论特性，表明它们是抗癌药物设计中有前景的先导分子。
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