Wyatt H, Herman O M, Macartney M, Conibear T, Garcia-Diaz A, Booth C, McCormick A, Smith C, Johnson M A, Irish D, Webster D P
Medical School, University College London, London, UK.
Department of Virology, Royal Free Hospital, London, UK.
Int J STD AIDS. 2015 Jul;26(8):593-4. doi: 10.1177/0956462414546917. Epub 2014 Aug 20.
A review of a large number of HIV-1 tropism test requests (n = 1148) performed at a London tertiary referral centre was carried out. The aim was to establish whether these were being performed in line with recommendations from published guidelines and whether this represented the most cost-effective use of these tests in informing prescribing decisions of the CCR5 antagonist drug, maraviroc. The cost of these assays within the UK was covered by commercial funding until April 2013 which has subsequently been withdrawn. Furthermore, all healthcare settings are under increasing cost constraints and hence establishing the real utility and appropriate use of these tests is of vital importance.
对伦敦一家三级转诊中心进行的大量HIV-1嗜性检测请求（n = 1148）进行了回顾。目的是确定这些检测是否符合已发表指南的建议，以及这是否代表了这些检测在为CCR5拮抗剂药物马拉维若的处方决策提供信息方面最具成本效益的用途。在2013年4月之前，英国境内这些检测的费用由商业资金支付，此后该资金已被撤回。此外，所有医疗保健机构都面临着日益增加的成本限制，因此确定这些检测的实际效用和合理使用至关重要。
