康复训练期间的迷走神经刺激可改善脑出血后的功能恢复。
Vagus nerve stimulation during rehabilitative training improves functional recovery after intracerebral hemorrhage.
作者信息
Hays Seth A, Khodaparast Navid, Hulsey Daniel R, Ruiz Andrea, Sloan Andrew M, Rennaker Robert L, Kilgard Michael P
机构信息
From the Erik Jonsson School of Engineering and Computer Science, Department of Bioengineering (S.A.H., A.M.S., R.L.R.), Texas Biomedical Device Center (S.A.H., N.K., D.R.H., A.R., R.L.R., M.P.K.), and School of Behavioral Brain Sciences (D.R.H., R.L.R., M.P.K.), The University of Texas at Dallas, Richardson.
出版信息
Stroke. 2014 Oct;45(10):3097-100. doi: 10.1161/STROKEAHA.114.006654. Epub 2014 Aug 21.
BACKGROUND AND PURPOSE
Vagus nerve stimulation (VNS) delivered during rehabilitative training enhances neuroplasticity and improves recovery in models of cortical ischemic stroke. However, VNS therapy has not been applied in a model of subcortical intracerebral hemorrhage (ICH). We hypothesized that VNS paired with rehabilitative training after ICH would enhance recovery of forelimb motor function beyond rehabilitative training alone.
METHODS
Rats were trained to perform an automated, quantitative measure of forelimb function. Once proficient, rats received an intrastriatal injection of bacterial collagenase to induce ICH. Rats then underwent VNS paired with rehabilitative training (VNS+Rehab; n=14) or rehabilitative training without VNS (Rehab; n=12). Rehabilitative training began ≥9 days after ICH and continued for 6 weeks.
RESULTS
VNS paired with rehabilitative training significantly improved recovery of forelimb function when compared with rehabilitative training without VNS. The VNS+Rehab group displayed a 77% recovery of function, whereas the Rehab group only exhibited 29% recovery. Recovery was sustained after cessation of stimulation. Both groups performed similar amounts of trials during rehabilitative, and lesion size was not different between groups.
CONCLUSIONS
VNS paired with rehabilitative training confers significantly improved forelimb recovery after ICH compared to rehabilitative training without VNS.
背景与目的
在康复训练期间进行迷走神经刺激（VNS）可增强神经可塑性，并改善皮质缺血性卒中模型的恢复情况。然而，VNS疗法尚未应用于皮质下脑出血（ICH）模型。我们假设，ICH后VNS与康复训练相结合能比单纯康复训练更有效地促进前肢运动功能恢复。
方法
训练大鼠进行前肢功能的自动定量测量。熟练后，大鼠接受纹状体内注射细菌胶原酶以诱导ICH。然后，大鼠接受VNS与康复训练相结合（VNS+康复训练组；n=14）或不进行VNS的康复训练（康复训练组；n=12）。康复训练在ICH后≥9天开始，并持续6周。
结果
与不进行VNS的康复训练相比，VNS与康复训练相结合显著改善了前肢功能恢复。VNS+康复训练组功能恢复率为77%，而康复训练组仅为29%。停止刺激后恢复情况持续存在。两组在康复训练期间进行的试验次数相似，且两组间的损伤大小无差异。
结论
与不进行VNS的康复训练相比，VNS与康复训练相结合能显著改善ICH后的前肢恢复情况。
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