Varni James W, Bendo Cristiane B, Denham Jolanda, Shulman Robert J, Self Mariella M, Neigut Deborah A, Nurko Samuel, Patel Ashish S, Franciosi James P, Saps Miguel, Yeckes Alyson, Langseder Annette, Saeed Shehzad, Pohl John F
Department of Pediatrics, College of Medicine, Texas A&M University, College Station, TX, USA,
Qual Life Res. 2015 Feb;24(2):363-78. doi: 10.1007/s11136-014-0781-x. Epub 2014 Aug 23.
The primary objective was to compare the gastrointestinal (GI) symptoms and worry of pediatric patients with functional GI disorders (FGIDs) and organic GI diseases to healthy controls utilizing the Pediatric Quality of Life Inventory™ (PedsQL™) Gastrointestinal Symptoms and Worry Scales for patient self-reports ages 5-18 years and parent proxy-reports for ages 2-18 years. The secondary objective was to compare FGIDs and organic GI diseases to each other.
The PedsQL™ Gastrointestinal Symptoms and Worry Scales were completed in a 9-site study by 587 pediatric patients with GI disorders and 685 parents of patients. Patients had physician-diagnosed GI disorders (chronic constipation, functional abdominal pain, irritable bowel syndrome, functional dyspepsia, Crohn's disease, ulcerative colitis, and gastroesophageal reflux disease). Ten Gastrointestinal Symptoms Scales measuring Stomach Pain, Stomach Discomfort When Eating, Food and Drink Limits, Trouble Swallowing, Heartburn and Reflux, Nausea and Vomiting, Gas and Bloating, Constipation, Blood, and Diarrhea were administered along with two Gastrointestinal Worry Scales. Five hundred and thirteen healthy children and 337 parents of healthy children completed the PedsQL™ Gastrointestinal Scales in an Internet panel survey.
The PedsQL™ Gastrointestinal Symptoms and Worry Scales distinguished between pediatric patients with FGIDs and organic GI diseases in comparison with healthy controls, supporting known-groups validity. Patients with FGIDs reported more GI symptoms and worry than patients with organic GI diseases.
The PedsQL™ Gastrointestinal Symptoms and Worry Scales may be utilized as common metrics across pediatric patient groups with FGIDs and organic GI diseases and healthy samples to measure GI-specific symptoms in clinical research and practice.
主要目的是利用儿童生活质量量表（PedsQL™）胃肠道症状和担忧量表，对功能性胃肠疾病（FGIDs）和器质性胃肠疾病的儿科患者与健康对照的胃肠道（GI）症状及担忧程度进行比较，其中5至18岁患者采用患者自评，2至18岁患者采用家长代评。次要目的是比较FGIDs与器质性胃肠疾病。
在一项9个地点参与的研究中，587名患有胃肠疾病的儿科患者和685名患者家长完成了PedsQL™胃肠道症状和担忧量表。患者患有经医生诊断的胃肠疾病（慢性便秘、功能性腹痛、肠易激综合征、功能性消化不良、克罗恩病、溃疡性结肠炎和胃食管反流病）。同时使用了10个胃肠道症状量表，分别测量胃痛、进食时胃部不适、饮食限制、吞咽困难、烧心和反流、恶心和呕吐、气体和腹胀、便秘、便血以及腹泻，还有2个胃肠道担忧量表。513名健康儿童和337名健康儿童的家长在一项网络小组调查中完成了PedsQL™胃肠道量表。
与健康对照相比，PedsQL™胃肠道症状和担忧量表能够区分患有FGIDs的儿科患者和器质性胃肠疾病患者，支持已知群体效度。FGIDs患者报告的胃肠道症状和担忧比器质性胃肠疾病患者更多。
PedsQL™胃肠道症状和担忧量表可作为FGIDs和器质性胃肠疾病的儿科患者群体以及健康样本的通用指标，用于临床研究和实践中测量胃肠道特异性症状。
