Zaragoza University, Edificio Betacourt (Campus Río Ebro), C/ Maria de Luna s/n, 50018 , Saragossa, Spain.
Biomech Model Mechanobiol. 2015 Apr;14(2):371-85. doi: 10.1007/s10237-014-0610-8. Epub 2014 Aug 23.
Slipped capital femoral epiphysis (SCFE) is one of the most common disorders of adolescent hips. A number of works have related the development of SCFE to mechanical factors. Due to the difficulty of diagnosing SCFE in its early stages, the disorder often progresses over time, resulting in serious side effects. Therefore, the development of a tool to predict the initiation of damage in the growth plate is needed. Because the growth plate is a heterogeneous structure, to develop a precise and reliable model, it is necessary to consider this structure from both macro- and microscale perspectives. Thus, the main objective of this work is to develop a numerical multi-scale model that links damage occurring at the microscale to damage occurring at the macroscale. The use of this model enables us to predict which regions of the growth plate are at high risk of damage. First, we have independently analyzed the microscale to simulate the microstructure under shear and tensile tests to calibrate the damage model. Second, we have employed the model to simulate damage occurring in standardized healthy and affected femurs during the heel-strike stage of stair climbing. Our results indicate that on the macroscale, damage is concentrated in the medial region of the growth plate in both healthy and affected femurs. Furthermore, damage to the affected femur is greater than damage to the healthy femur from both the micro- and macrostandpoints. Maximal damage is observed in territorial matrices. Furthermore, simulations illustrate that little damage occurs in the reserve zone. These findings are consistent with previous findings reported in well-known experimental works.
股骨头骨骺滑脱症（SCFE）是青少年髋关节最常见的疾病之一。许多研究将 SCFE 的发展与机械因素联系起来。由于早期诊断 SCFE 的难度，该疾病通常会随着时间的推移而进展，导致严重的副作用。因此，需要开发一种预测生长板损伤起始的工具。由于生长板是一种不均匀的结构，为了开发精确和可靠的模型，有必要从宏观和微观两个角度考虑这种结构。因此，这项工作的主要目的是开发一个数值多尺度模型，将微观尺度上的损伤与宏观尺度上的损伤联系起来。使用该模型，我们可以预测生长板的哪些区域容易受到损伤。首先，我们独立分析了微观尺度，模拟了剪切和拉伸试验下的微观结构，以校准损伤模型。其次，我们使用该模型模拟了在爬楼梯的脚跟冲击阶段中标准化的健康和受影响的股骨中发生的损伤。我们的结果表明，在宏观尺度上，健康和受影响的股骨的生长板中部区域都集中了损伤。此外，从微观和宏观两个角度来看，受影响股骨的损伤大于健康股骨的损伤。在 territorial matrices 中观察到最大的损伤。此外，模拟表明储备区几乎没有损伤。这些发现与之前在著名的实验工作中报道的结果一致。
