Rowberry Justin, Macari Suzanne, Chen Grace, Campbell Daniel, Leventhal John M, Weitzman Carol, Chawarska Katarzyna
Developmental and Behavioral Pediatrics, Mike O'Callaghan Federal Medical Center, 4700 Las Vegas Boulevard North, Building 1300, Nellis Air Force Base, NV, 89191, USA,
J Autism Dev Disord. 2015 Jan;45(1):221-9. doi: 10.1007/s10803-014-2211-x.
This study examines whether parental report of social-communicative and repetitive behaviors at 12 months can be helpful in identifying autism spectrum disorder (ASD) in younger siblings of children with ASD [high-risk (HR)-siblings]. Parents of HR-siblings and infants without a family history of ASD completed the First Year Inventory at 12 months. Developmental outcomes were based on 24- or 36-month assessments. HR-siblings later diagnosed with ASD showed greater impairments in social communication than those with other developmental outcomes based on parental and clinician ratings. Parental report of decline in play and communication and impaired vocal imitation correctly classified a majority of ASD cases with high specificity. These preliminary findings have important implications for the development of early screening instruments for ASD in HR-siblings.
本研究探讨12个月大时父母报告的社交沟通和重复行为，是否有助于识别自闭症谱系障碍（ASD）患儿（高危[HR]兄弟姐妹）的年幼同胞中的ASD。HR兄弟姐妹和无ASD家族史婴儿的父母在12个月时完成了第一年问卷。发育结果基于24个月或36个月的评估。根据父母和临床医生的评分，后来被诊断为ASD的HR兄弟姐妹在社交沟通方面的损伤比有其他发育结果的兄弟姐妹更大。父母报告的玩耍和沟通能力下降以及发声模仿受损，以高特异性正确分类了大多数ASD病例。这些初步发现对开发HR兄弟姐妹ASD早期筛查工具具有重要意义。
