[异基因造血干细胞移植后吉兰-巴雷综合征：两例报告及文献复习]
[Guillain-Barre syndrome after allogeneic hematopoietic stem cell transplantation: two cases report and literature review].
作者信息
Xu Xiaoqian, Jia Lin, Chen Li, Zhang Weiping, Wang Jianmin
机构信息
Department of Hematology, Changhai Hospital Affiliated to Secondary Military Medical University, Shanghai 200433, China.
出版信息
Zhonghua Xue Ye Xue Za Zhi. 2014 Aug;35(8):694-7. doi: 10.3760/cma.j.issn.0253-2727.2014.08.005.
OBJECTIVE
To investigate the clinical characteristics, treatment and prognosis of Guillain-Barre syndrome (GBS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
METHODS
Two cases with GBS after allo-HSCT were admitted to our hospital and a review of literatures concerning GBS developed after allo-HSCT. The clinical characteristics, treatment and prognosis were investigated.
RESULTS
Two patients experienced sensory disturbance and progressive muscle weakness 2 months after HSCT. The diagnosis of GBS was established after cranial MRI, lumbar puncture and EMG. Both patients died of GBS progression even after the treatment of steroid, intravenous immunoglobulin (IVIG) and plasma exchange.
CONCLUSION
GBS was a rare complication after allo-HSCT. The common clinical practices in treating GBS included IVIG and plasma exchange. Due to the primary malignant disease and low immunity posttransplant, infection, GVHD and other complications, prognosis of GBS was poor with high mortality.
目的
探讨异基因造血干细胞移植（allo-HSCT）后吉兰-巴雷综合征（GBS）的临床特征、治疗及预后。
方法
我院收治2例allo-HSCT后发生GBS的患者，并对allo-HSCT后发生GBS的相关文献进行回顾。对其临床特征、治疗及预后进行研究。
结果
2例患者在HSCT后2个月出现感觉障碍和进行性肌无力。经头颅MRI、腰椎穿刺及肌电图检查确诊为GBS。尽管给予了类固醇、静脉注射免疫球蛋白（IVIG）及血浆置换治疗，2例患者均死于GBS进展。
结论
GBS是allo-HSCT后一种罕见的并发症。治疗GBS的常用方法包括IVIG及血浆置换。由于存在原发性恶性疾病及移植后免疫力低下，感染、移植物抗宿主病（GVHD）及其他并发症，GBS预后较差，死亡率高。
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