[ED50 of dexmedetomidine nasal drip in induction of hypnosis in children during computed tomography].
作者信息
Xu Yingyi, Song Xingrong, Zhang Guoqiang
机构信息
Department of Anesthesiology,Guangzhou Women and Children's Medical Center,Guangzhou 510120, China.
Department of Anesthesiology,Guangzhou Women and Children's Medical Center,Guangzhou 510120, China. Email:
出版信息
Zhonghua Yi Xue Za Zhi. 2014 Jun 24;94(24):1886-8.
OBJECTIVE
To explore the 50% effective dose (ED₅₀) of dexmedetomidine nasal drip in the induction of hypnosis in children during computed tomography (CT).
METHODS
A total of 34 American Society of Anesthesiologists (ASA)I-IIautistic children scheduled for brain CT examination were studied. The induction was made by dexmedetomidine nasal drip and the ED₅₀ of dexmedetomidine determined by up-and down sequential experiment.When eyelash reflex became lost or Ramsay score was ≥ 4 in 1 hour after dosing, hypnosis was achieved. The study ended after 8 crossovers (successive "accept" and "refuse").
RESULTS
Among them, the ED₅₀ of dexmedetomidine was 1.76 µg/kg (95% confident interval:1.64-1.88 µg/kg).
CONCLUSION
The ED₅₀ of dexmedetomidine nasal drip is 1.76 µg/kg in the induction of hypnosis in children.
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