Excitotoxicity of NMDA and kainic acid is modulated by nigrostriatal dopaminergic fibres.
作者信息
Chapman A G, Dürmuller N, Lees G J, Meldrum B S
机构信息
Department of Neurology, Institute of Psychiatry, London, U.K.
出版信息
Neurosci Lett. 1989 Dec 15;107(1-3):256-60. doi: 10.1016/0304-3940(89)90827-6.
PMID:2515501
Abstract
The excitotoxic action of N-methyl-D-aspartate (NMDA) and of kinase (KA) has been assessed by measuring glutamic acid decarboxylase (GAD) and choline acetyltransferase (ChAT) activity in the rat striatum 5 days after focal microinjections of NMDA or KA. Prior unilateral lesioning of the nigrostriatal dopaminergic pathway by focal injection of 6-hydroxydopamine decreases the excitotoxic effect of NMDA and of KA.
摘要
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