硝酸镓和苹果酸镓对副结核分枝杆菌体外抗菌活性的比较。

Comparison of the antimicrobial activities of gallium nitrate and gallium maltolate against Mycobacterium avium subsp. paratuberculosis in vitro.

作者信息

Fecteau Marie-Eve, Aceto Helen W, Bernstein Lawrence R, Sweeney Raymond W

机构信息

Department of Clinical Studies-New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, 382 West Street Rd, Kennett Square, PA 19348, United States.

出版信息

Vet J. 2014 Oct;202(1):195-7. doi: 10.1016/j.tvjl.2014.06.023. Epub 2014 Jul 3.

DOI:10.1016/j.tvjl.2014.06.023

PMID:25155307

Abstract

Johne's disease (JD) is an enteric infection of cattle and other ruminants caused by Mycobacterium avium subsp. paratuberculosis (MAP). This study compared the antimicrobial activities of gallium nitrate (GaN) and gallium maltolate (GaM) against two field MAP isolates by use of broth culture. The concentrations that resulted in 99% growth inhibition of isolates 1 and 2 were, respectively, 636 µM and 183 µM for GaN, and 251 µM and 142 µM for GaM. For both isolates, time to detection was significantly higher for GaM than GaN. These results suggest that GaM is more efficient than GaN in inhibiting MAP growth in vitro.

摘要

副结核（JD）是由鸟分枝杆菌副结核亚种（MAP）引起的牛和其他反刍动物的一种肠道感染。本研究通过肉汤培养比较了硝酸镓（GaN）和麦芽酚镓（GaM）对两株MAP野外分离株的抗菌活性。导致分离株1和2生长抑制99%的浓度，GaN分别为636µM和183µM，GaM分别为251µM和142µM。对于这两株分离株，GaM的检测时间均显著长于GaN。这些结果表明，在体外抑制MAP生长方面，GaM比GaN更有效。