McBrearty Jordan, Barker David, Damavandi Mona, Wilson-Nieuwenhuis Joels, Pilkington Lisa I, Dempsey-Hibbert Nina, Slate Anthony J, Whitehead Kathryn A
Microbiology at Interfaces Group, Faculty of Science and Engineering, Manchester Metropolitan University Manchester M1 5GD UK
School of Chemical Sciences, University of Auckland Auckland 1010 New Zealand.
RSC Adv. 2018 Jun 27;8(41):23433-23441. doi: 10.1039/c8ra02673d. eCollection 2018 Jun 21.
The rise in multidrug resistant bacteria is an area of growing concern and it is essential to identify new biocidal agents. Cationic grafted compounds were investigated for their antimicrobial properties using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests. Synergy testing was carried out using the compounds in the presence of ultraviolet (UV). Fractional inhibitory concentration (FIC) and fractional bactericidal concentration (FBC) tests were carried out using the cationic molecules in conjunction with metal ion solutions of gold, silver, palladium, platinum, rhodium, titanium, tin, vanadium and molybdenum. Individually, the cationic compounds containing quaternary amines, polyphenylene vinylene (PPV) with long polyacrylate grafts (PPV--PMETAC (HMw)), polyphenylene ethylene (PPE) with long polyacrylate grafts (PPE--PMETAC (HMw)), polyphenylene vinylene (PPV) with short polyacrylate grafts (PPV--PMETAC (LMw)) and polyphenylene ethylene (PPE) with short polyacrylate grafts (PPE--PMETAC (LMw)) were effective against . The most successful compound under UV was PPV--PMETAC (HMw). Following the FICs, palladium and rhodium ion solutions caused a synergistic reaction with all four tested compounds. The presence of conjugated bonds in the cationic molecules increased its antimicrobial activity. These results suggest that the chemical backbone of the compounds, alongside the chain lengths and chain attachment affect the antimicrobial efficacy of a compound. These factors should be taken into consideration when formulating new biocidal combinations.
多重耐药菌的增加是一个日益受到关注的领域，识别新型杀菌剂至关重要。使用最低抑菌浓度（MIC）和最低杀菌浓度（MBC）测试研究了阳离子接枝化合物的抗菌性能。在紫外线（UV）存在的情况下使用这些化合物进行协同测试。使用阳离子分子与金、银、钯、铂、铑、钛、锡、钒和钼的金属离子溶液联合进行部分抑菌浓度（FIC）和部分杀菌浓度（FBC）测试。单独来看，含季胺的阳离子化合物、带有长聚丙烯酸酯接枝的聚亚苯基乙烯撑（PPV-PMETAC（高分子量））、带有长聚丙烯酸酯接枝的聚亚苯基乙烯（PPE-PMETAC（高分子量））、带有短聚丙烯酸酯接枝的聚亚苯基乙烯撑（PPV-PMETAC（低分子量））和带有短聚丙烯酸酯接枝的聚亚苯基乙烯（PPE-PMETAC（低分子量））对……有效。在紫外线照射下最成功的化合物是PPV-PMETAC（高分子量）。根据FIC结果，钯和铑离子溶液与所有四种测试化合物发生协同反应。阳离子分子中共轭键的存在增加了其抗菌活性。这些结果表明，化合物的化学主链以及链长和链连接方式会影响化合物的抗菌效果。在配制新型杀菌组合时应考虑这些因素。
