Campos R, Pinto P L, Amato Neto V, Moreira A A
Rev Hosp Clin Fac Med Sao Paulo. 1989 May-Jun;44(3):111-4.
The efficacy of an association of oxamniquine and praziquantel in the patent phase of experimental schistosomiasis was studied. The mice were infected and divided in four groups in accordance to the following schedules with the use of single oral doses: I--Oxaminiquine (50 mg/kg); II--praziquantel (75 mg/kg); III--association of oxamniquine (50 mg/kg) and praziquantel (75 mg/kg); and IV--no drug. Efficacy was assessed by the oogram technique, studying and classifying the evolution of the output of eggs in fragments of the small intestine, and also by recovery of the worms by portal vein perfusion. In the animals of groups I and II, the drugs had a partial effect while in the group III sinergism was evident.
研究了奥沙尼喹与吡喹酮联合使用在实验性血吸虫病成虫期的疗效。小鼠感染后，按照以下方案单剂量口服给药分为四组：I组——奥沙尼喹（50毫克/千克）；II组——吡喹酮（75毫克/千克）；III组——奥沙尼喹（50毫克/千克）与吡喹酮（75毫克/千克）联合使用；IV组——不给药。通过虫卵计数技术评估疗效，研究并分类小肠片段中虫卵排出量的变化情况，同时通过门静脉灌注回收虫体来评估疗效。在I组和II组动物中，药物有部分作用，而在III组中协同作用明显。
