吡喹酮和奥沙尼喹对小鼠体内沙特阿拉伯曼氏血吸虫株的作用。

Effects of praziquantel and oxamniquine on a Saudi Arabian strain of Schistosoma mansoni in mice.

作者信息

Ghandour A M, Banaja A A, Shalaby I M

机构信息

Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.

出版信息

J Helminthol. 1990 Mar;64(1):62-4. doi: 10.1017/s0022149x00011895.

DOI:10.1017/s0022149x00011895

PMID:2110944

Abstract

The prophylactic and curative effects of praziquantel and oxamniquine on a Saudi Arabian strain of Schistosoma mansoni in MF-1 mice were assessed. The drugs were administered orally. At 240 mg/kg praziquantel, there was a reduction of 89.1% in adult worm recovery and a marked reduction in tissue deposited eggs. The reduction in adult worm recovery after dosing with 50 mg/kg oxamniquine was 89.2%. At low doses (40 mg/kg praziquantel and 30 mg/kg oxamniquine) administered at 11 days, 5 days and 3 h before and 5, 21 and 49 days after infection, the reduction in adult worm recovery was 0.0%, 65.1%, 58.8%, 33.6%, 0.0% and 76.0% for praziquantel and 0.0%, 66.0%, 60.0%, 41.3%, 10.8% and 79.0% for oxamniquine. Numbers of lung schistosomula and the size of hepatic granulomata were also reduced.

摘要

评估了吡喹酮和奥沙尼喹对MF-1小鼠体内沙特阿拉伯曼氏血吸虫株的预防和治疗效果。药物通过口服给药。给予240mg/kg吡喹酮时，成虫回收率降低了89.1%，组织内沉积虫卵显著减少。给予50mg/kg奥沙尼喹后，成虫回收率降低了89.2%。在感染前11天、5天和3小时以及感染后5天、21天和49天给予低剂量（40mg/kg吡喹酮和30mg/kg奥沙尼喹）时，吡喹酮的成虫回收率降低分别为0.0%、65.1%、58.8%、33.6%、0.0%和76.0%，奥沙尼喹分别为0.0%、66.0%、60.0%、41.3%、10.8%和79.0%。肺内童虫数量和肝脏肉芽肿大小也有所减少。