评论：捕捉乙醇致畸性的保守机制。
Commentary: catching a conserved mechanism of ethanol teratogenicity.
作者信息
Lovely C Ben, Eberhart Johann K
机构信息
Department of Molecular Biosciences, Waggoner Center for Alcohol & Addiction Research, Institute for Cell and Molecular Biology, University of Texas at Austin, Austin, Texas.
出版信息
Alcohol Clin Exp Res. 2014 Aug;38(8):2160-3. doi: 10.1111/acer.12484.
BACKGROUND
Due to its profound impact on human development, ethanol (EtOH) teratogenicity is a field of intense study. The complexity of variables that influence the outcomes of embryonic or prenatal EtOH exposure compels the use of animal models in which these variables can be isolated.
METHODS
Numerous model systems have been used in these studies. The zebrafish is a powerful model system, which has seen a recent increase in usage for EtOH studies.
RESULTS
Those using zebrafish for alcohol studies often face 2 questions: (i) How physiologically relevant are the doses of EtOH administered to zebrafish embryos? and (ii) Will the mechanisms of EtOH teratogenesis be conserved to other model systems and human?
CONCLUSIONS
The current article by Flentke and colleagues () helps to shed important light on these questions and clearly demonstrates that the zebrafish will be a valuable model system with which to understand EtOH teratogenicity.
背景
由于乙醇（EtOH）致畸性对人类发育有深远影响，它是一个深入研究的领域。影响胚胎期或孕期乙醇暴露结果的变量十分复杂，这使得人们不得不使用能够分离这些变量的动物模型。
方法
这些研究中使用了众多模型系统。斑马鱼是一种强大的模型系统，近期在乙醇研究中的使用有所增加。
结果
那些使用斑马鱼进行酒精研究的人通常会面临两个问题：（i）给予斑马鱼胚胎的乙醇剂量在生理上的相关性如何？以及（ii）乙醇致畸机制是否会在其他模型系统和人类中保守？
结论
弗伦特克及其同事的这篇文章有助于阐明这些问题，并清楚地表明斑马鱼将成为理解乙醇致畸性的一个有价值的模型系统。
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