Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, PO BOX 208057, 333 Cedar Street, New Haven, CT 06520-8057, USA.
Section of Pulmonary, Critical Care and Sleep Medicine, Yale University School of Medicine, PO BOX 208057, 333 Cedar Street, New Haven, CT 06520-8057, USA.
Clin Chest Med. 2014 Sep;35(3):505-12. doi: 10.1016/j.ccm.2014.06.006. Epub 2014 Jul 24.
Restrictive lung disease leads to ventilatory defects and diffusion impairments. These changes may contribute to abnormal nocturnal pathophysiology, including sleep architecture disruption and impaired ventilation and oxygenation. Patients with restrictive lung disease may suffer significant daytime fatigue and dysfunction. Hypercarbia and hypoxemia during sleep may impact progression of lung disease and related symptoms. Little is known about the impact of treatment of sleep disruption on sleep quality and overall prognosis in restrictive lung disease. This review discusses the pathophysiology of sleep and comorbid sleep disorders in restrictive lung diseases including interstitial lung disease, neuromuscular disease, and obesity hypoventilation syndrome.
限制性肺疾病可导致通气缺陷和弥散功能障碍。这些变化可能导致异常的夜间病理生理学改变，包括睡眠结构破坏以及通气和氧合受损。限制性肺疾病患者可能会经历显著的日间疲劳和功能障碍。睡眠期间的高碳酸血症和低氧血症可能会影响肺疾病的进展和相关症状。关于治疗睡眠障碍对限制性肺疾病的睡眠质量和整体预后的影响，目前知之甚少。本文讨论了睡眠的病理生理学以及包括间质性肺疾病、神经肌肉疾病和肥胖低通气综合征在内的限制性肺疾病中的合并睡眠障碍。
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