Foley-Nolan D, Foley-Nolan A, Temperley D, Devlin J
Ir Med J. 1989 Dec;82(4):159-60.
Sixteen insulin-dependent diabetics commenced continuous subcutaneous insulin infusion (CSII) pumps either because of poor control (15 patients), or because of preference (1 patient). The study examined the diabetic control achieved, patients attitudes and CSII pump complications. Statistically significant improvements in HbAlC which fell from a pre-treatment mean of 12.57% to 10.0% at three months (p less than 0.01) and 10.6% at six months (p less than 0.02) were achieved. At nine months the improvement was not statistically significant. Fourteen of the 16 patients wished at the end of one year to continue this treatment. This study reports a low rate of symptomatic hypoglycaemia and infusion site infection. However, there was a large number of cases of ketoacidosis which highlights the need for extreme vigilance in monitoring patients treated by this method.
16名胰岛素依赖型糖尿病患者开始使用持续皮下胰岛素输注(CSII)泵,其中15名是因为血糖控制不佳,1名是出于个人偏好。该研究考察了血糖控制情况、患者态度以及CSII泵相关并发症。糖化血红蛋白(HbAlC)有统计学意义的改善,治疗前平均为12.57%,三个月时降至10.0%(p<0.01),六个月时降至10.6%(p<0.02)。九个月时改善无统计学意义。16名患者中有14名在一年结束时希望继续这种治疗。该研究报告称有症状性低血糖和输注部位感染的发生率较低。然而,有大量酮症酸中毒病例,这突出表明对采用这种方法治疗的患者进行监测时需要极度警惕。