高等灵长类动物，而非新大陆猴，在其载脂蛋白C-I基因两侧有一组重复的增强子。
Higher primates, but not New World monkeys, have a duplicate set of enhancers flanking their apoC-I genes.
作者信息
Puppione Donald L
机构信息
The Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA.
出版信息
Comp Biochem Physiol Part D Genomics Proteomics. 2014 Sep;11:45-8. doi: 10.1016/j.cbd.2014.08.001. Epub 2014 Aug 13.
Previous studies have demonstrated that the apoC-I gene and its pseudogene on human chromosome 19 are flanked by a duplicate set of enhancers. Multienhancers, ME.1 and ME.2, are located upstream from the genes and the hepatic control region enhancers, HCR.1 and HCR.2, are located downstream. The duplication of the enhancers has been thought to have occurred when the apoC-I gene was duplicated during primate evolution. Currently, the only primate data are for the human enhancers. Examining the genome of other primates (great and lesser apes, Old and New World monkeys), it was possible to locate the duplicate set of enhancers in apes and Old World monkeys. However, only a single set was found in New World monkeys. These observations provide additional evidence that the apoC-I gene and the flanking enhancers underwent duplication after the divergence of Old and New World monkeys.
先前的研究表明，人类19号染色体上的载脂蛋白C-I基因及其假基因两侧有一组重复的增强子。多增强子ME.1和ME.2位于基因上游，而肝脏控制区增强子HCR.1和HCR.2位于下游。人们认为，在灵长类动物进化过程中载脂蛋白C-I基因发生复制时，增强子也随之复制。目前，仅有人类增强子的灵长类动物数据。通过研究其他灵长类动物（大猩猩、小黑猩猩、旧世界猴和新世界猴）的基因组，有可能在猿类和旧世界猴中定位到这组重复的增强子。然而，在新世界猴中仅发现了一组。这些观察结果提供了额外的证据，表明在旧世界猴和新世界猴分化之后，载脂蛋白C-I基因及其侧翼增强子发生了复制。
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