在镍催化剂存在下，脂肪族酰胺中C(sp3)-H键与二芳基碘鎓盐的直接芳基化反应。
Direct arylation of C(sp3)-H bonds in aliphatic amides with diaryliodonium salts in the presence of a nickel catalyst.
作者信息
Iyanaga Miki, Aihara Yoshinori, Chatani Naoto
机构信息
Department of Applied Chemistry, Faculty of Engineering, Osaka University , Suita, Osaka 565-0871, Japan.
出版信息
J Org Chem. 2014 Dec 19;79(24):11933-9. doi: 10.1021/jo501691f. Epub 2014 Sep 4.
The Ni(II)-catalyzed direct arylation of C(sp(3))-H (methyl and methylene) bonds in aliphatic amides containing an 8-aminoquinoline moiety as the directing group with diaryliodonium salts as coupling electrophiles is described. A wide variety of functional groups are tolerated in the reaction. The reaction represents the first example of the Ni-catalyzed direct arylation of C(sp(3))-H bonds with diaryliodonium salts.
描述了以含8-氨基喹啉部分作为导向基团的脂肪族酰胺中的C(sp(3))-H（甲基和亚甲基）键为底物，二芳基碘鎓盐作为偶联亲电试剂，通过镍(II)催化的直接芳基化反应。该反应对多种官能团具有耐受性。此反应代表了镍催化C(sp(3))-H键与二芳基碘鎓盐直接芳基化反应的首例。
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