镍催化未活化C(sp³)-H键与芳基卤化物的螯合辅助直接芳基化反应。
Nickel-catalyzed chelation-assisted direct arylation of unactivated C(sp3)-H bonds with aryl halides.
作者信息
Li Mingliang, Dong Jiaxing, Huang Xiaolei, Li Kaizhi, Wu Qian, Song Feijie, You Jingsong
机构信息
Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064, PR China.
出版信息
Chem Commun (Camb). 2014 Apr 18;50(30):3944-6. doi: 10.1039/c4cc00716f. Epub 2014 Mar 5.
In this work, we have disclosed the nickel-catalyzed unactivated β-C(sp(3))-H bond arylation of aliphatic acid derivatives with aryl iodides/bromides via bidentate chelation-assistance of an 8-aminoquinoline moiety. These preliminary results indicate the intrinsic catalytic potential of nickel metal for unactivated C(sp(3))-H bond arylation.
在本研究中，我们通过8-氨基喹啉部分的双齿螯合辅助作用，揭示了镍催化脂肪族酸衍生物与芳基碘化物/溴化物之间未活化的β-C(sp(3))-H键芳基化反应。这些初步结果表明了镍金属在未活化的C(sp(3))-H键芳基化反应中的内在催化潜力。
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