Krut'ko V N, Dontsov V I, Zakhar'iashcheva O V, Kuznetsov I A, Mamikonova O A, Pyrvu V V, Smirnova T M, Sokolova L A
Aviakosm Ekolog Med. 2014;48(3):12-9.
Methodology of estimating the integral health and aging level is based on the system index of biological age (BA). The paper introduces the reader to the BA principles and structure, search for meaningful aging biomarkers, useful tests, and applications in present-day biomedicine. The concept of BA is directly linked with the theory of organism vitality. BA biomarkers must provide a detailed picture of the process of aging. Number of biomarkers cannot be large, while their changes with aging must be uniform in every population member and fairly distinct though with moderate interindividual variations. Prognosis of the vital trajectory requires estimation of risk factors, i.e. hereditary and acquired factors that affect lifespan, and also longevity factors, i.e. genetic and environmental factors crucial for clinical medicine and gerontological prophylaxis properly. At present, BA gains wide recognition in clinical and preventive medicine, physiology and biology as a method to evaluate the general state of health, ecological well-being, adaptation to extreme factors, as well as the rate and degree of organism aging.
评估整体健康和衰老水平的方法基于生物年龄（BA）的系统指标。本文向读者介绍了生物年龄的原理和结构、寻找有意义的衰老生物标志物、有用的测试以及在当代生物医学中的应用。生物年龄的概念与机体活力理论直接相关。生物年龄生物标志物必须提供衰老过程的详细情况。生物标志物的数量不能太多，而它们随衰老的变化在每个个体中必须是一致的，并且相当明显，尽管个体间存在适度差异。生命轨迹的预后需要评估危险因素，即影响寿命的遗传和后天因素，以及长寿因素，即对临床医学和老年预防至关重要的遗传和环境因素。目前，生物年龄作为一种评估健康总体状况、生态福祉、对极端因素的适应能力以及机体衰老速度和程度的方法，在临床和预防医学、生理学和生物学中得到了广泛认可。
