García Martín F, Donnay Candil S, Martín Escobar E, Alvaro R, de Arriba G, Requejo R, Martín Hernández R
Rev Clin Esp. 1989 Nov;185(8):399-401.
The Growth Hormone Releasing Hormone (GH-RH) constitutes the most potent and specific stimulus for Growth Hormone secretion. Nevertheless, in some pathologic situations a Prolactin (PRL) response to GH-RH stimulus is also observed. In order to evaluate the possible effect of GH-RH over seric levels of PRL in uremic patients we carried out a study in a group of ten male patients on hemodialysis (HD), who were given an acute stimulus of GH-RH (an IV 50 mcg. bolus) immediately before and after the HD session, with blood extractions at times -15, 0, 15, 30, 45, 60, and 90 minutes for PRL determinations. The same procedure was carried out in 8 healthy controls. Basal PRL levels in the HD group (14 +/- 3.2 micrograms/L) were significantly greater (p less than 0.01) than control group (3.8 +/- 1.4 micrograms/L). There was no PRL response to GH-RH either in uremic patients before or after HD or in healthy controls. Our results show that there is a significant increase in PRL levels in uremic patients both before and after dialysis with a GH-RH response comparable to healthy subjects.
生长激素释放激素（GH-RH）是生长激素分泌最有效且最具特异性的刺激因素。然而，在某些病理情况下，也观察到催乳素（PRL）对GH-RH刺激有反应。为了评估GH-RH对尿毒症患者血清PRL水平的可能影响，我们对一组10名接受血液透析（HD）的男性患者进行了一项研究，在HD治疗前后立即给予他们一次GH-RH急性刺激（静脉注射50微克推注），并在-15、0、15、30、45、60和90分钟时采血测定PRL。8名健康对照者也进行了相同的操作。HD组的基础PRL水平（14±3.2微克/升）显著高于对照组（3.8±1.4微克/升）（p<0.01）。尿毒症患者在HD前后以及健康对照者对GH-RH均无PRL反应。我们的结果表明，尿毒症患者在透析前后PRL水平均显著升高，其对GH-RH的反应与健康受试者相当。
