Bos G M, Majoor G D, Van Breda Vriesman P J
Department of Immunology, University of Limburg, Maastricht, The Netherlands.
Thymus. 1989;14(1-3):155-61.
Lethally irradiated rats reconstituted with syngeneic bone marrow and treated for 40 or 80 days with Cyclosporin A (Cy-A) contract disease mimicking graft-versus-host disease about 3 weeks after withdrawal of the drug. We investigated the reconstitution of peripheral blood lymphocytes after this treatment. A selective effect on the regeneration of the CD4+ cells was observed. During Cy-A administration CD4(+)-cell regeneration was almost completely suppressed, but within 3 weeks after withdrawal of the drug such cells reappeared in blood and reached pre-irradiation levels about 6 weeks later. The coincidence of the reappearance of CD4+ cells and the onset of autoimmune disease suggests a causal relation between both events.
用同基因骨髓重建并经环孢素A（Cy - A）治疗40天或80天的致死性照射大鼠，在停药后约3周会出现类似移植物抗宿主病的疾病。我们研究了这种治疗后外周血淋巴细胞的重建情况。观察到对CD4 +细胞再生有选择性作用。在给予Cy - A期间，CD4(+)细胞再生几乎完全受到抑制，但在停药后3周内，此类细胞重新出现在血液中，并在约6周后达到照射前水平。CD4 +细胞的重新出现与自身免疫性疾病的发作同时发生，这表明这两个事件之间存在因果关系。
