Abelson Amanda L, Shelton G Diane, Whelan Megan F, Cornejo Lilian, Shaw Scott, O'Toole Therese E
Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01356Department of Pathology, University of California, San Diego, La Jolla, CA 9037Department of Emergency and Critical Care, Angell Animal Medical Center, Boston, MA 02130.
J Vet Emerg Crit Care (San Antonio). 2009 Aug;19(4):369-74. doi: 10.1111/j.1476-4431.2009.00433.x. Epub 2009 Jul 28.
To describe the use of IV and oral mycophenolate mofetil (MMF) as adjunctive therapy in 3 dogs with severe generalized myasthenia gravis.
Three dogs suffering from severe generalized myasthenia gravis as confirmed by acetylcholine antibody titers were treated with MMF as part of their treatment regimens. All 3 dogs had radiographic evidence of megaesophagus and suffered from severe regurgitation. Each dog was initially treated with pyridostigmine and supportive agents. When clinical remission was not achieved, IV MMF was administered to all dogs. Signs of clinical remission were apparent within 48 hours and all dogs were later maintained on oral MMF following resolution of regurgitation.
This is the first report of the use of IV MMF as adjunctive treatment in dogs with severe generalized myasthenia gravis. Outcome was favorable in all 3 dogs and no adverse effects were noted from the MMF.
描述静脉注射和口服霉酚酸酯（MMF）作为3只患有严重全身性重症肌无力犬的辅助治疗方法。
3只经乙酰胆碱抗体滴度确诊患有严重全身性重症肌无力的犬接受了MMF治疗，作为其治疗方案的一部分。所有3只犬均有食管扩张的影像学证据，并患有严重反流。每只犬最初都接受了吡啶斯的明和支持性药物治疗。当未实现临床缓解时，所有犬均接受了静脉注射MMF。48小时内出现临床缓解迹象，所有犬在反流症状缓解后均改为口服MMF维持治疗。
这是首次报道静脉注射MMF作为严重全身性重症肌无力犬辅助治疗的应用。所有3只犬的治疗效果良好，且未观察到MMF的不良反应。
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