Baek Hayeon, Yang Seung-Woo, Kim Seulki, Lee Yunseok, Park Hwi, Park Min, Jeon Byung-Ju, Park Hanwool, Hwang Han-Sung, Kim Joon-Young, Kim Jung-Hyun, Kang Young-Sun
Department of KONKUK-KIST Biomedical Science & Technology, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, Republic of Korea.
Sanford Consortium for Regenerative Medicine, School of Medicine, University of California, San Diego, CA 92037, USA.
Int J Mol Sci. 2025 Mar 5;26(5):2329. doi: 10.3390/ijms26052329.
DC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin) is a C-type lectin receptor expressed on dendritic cells and M2 macrophages, playing a key role in immune regulation and pathogen recognition. Its ability to mediate anti-inflammatory effects by interacting with specific ligands triggers pathways that suppress pro-inflammatory responses and promote tissue repair, making it a potential therapeutic target for inflammatory and autoimmune diseases. DC-SIGN homologs in various animal species share structural similarities and perform comparable immune functions, offering valuable insights into its broader application across species. By recognizing carbohydrate ligands on pathogens, DC-SIGN facilitates immune modulation, which can be harnessed for developing therapies aimed at controlling inflammation. In veterinary medicine, autoimmune and inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease, represent significant challenges, and the anti-inflammatory properties of DC-SIGN could provide new therapeutic options to improve disease management and enhance animal health. Future investigations should focus on the structural and functional analysis of DC-SIGN homologs in various species, as well as the development of preclinical models to translate these findings into clinical interventions bridging veterinary and human health.
DC-SIGN（树突状细胞特异性细胞间粘附分子3结合非整合素）是一种在树突状细胞和M2巨噬细胞上表达的C型凝集素受体，在免疫调节和病原体识别中起关键作用。它通过与特定配体相互作用介导抗炎作用的能力触发了抑制促炎反应和促进组织修复的途径，使其成为炎症和自身免疫性疾病的潜在治疗靶点。各种动物物种中的DC-SIGN同源物具有结构相似性并执行类似的免疫功能，为其在跨物种中的更广泛应用提供了有价值的见解。通过识别病原体上的碳水化合物配体，DC-SIGN促进免疫调节，这可用于开发旨在控制炎症的疗法。在兽医学中，类风湿性关节炎和炎症性肠病等自身免疫性和炎症性疾病是重大挑战，而DC-SIGN的抗炎特性可为改善疾病管理和提高动物健康提供新的治疗选择。未来的研究应集中于对各种物种中DC-SIGN同源物的结构和功能分析，以及开发临床前模型，以将这些发现转化为连接兽医学和人类健康的临床干预措施。
