Lakhani M, Khurshid M, Naqvi S H, Akber M
J Pak Med Assoc. 1989 Nov;39(11):282-4.
Congenital hypothyroidism is a preventable cause of mental retardation. Since clinical signs of congenital hypothyroidism do not generally become obvious before three months of age, screening programmes have been introduced in North America and Europe, which consist of T4 or TSH screening on newborn infants on the third day of life. The screening for congenital hypothyroidism was initiated in Pakistan by the Aga Khan University Hospital (AKUH) in March 1987. By April 1988, 5000 neonates were screened and five cases of congenital hypothyroidism were diagnosed. The study revealed the incidence of hypothyroidism to be one case per 1000 newborns which is about 4 times more than that in the West.
先天性甲状腺功能减退症是导致智力发育迟缓的一个可预防因素。由于先天性甲状腺功能减退症的临床症状通常在三个月龄之前不会变得明显，北美和欧洲已推行筛查项目，即在新生儿出生第三天对其进行T4或促甲状腺激素（TSH）筛查。1987年3月，阿迦汗大学医院（AKUH）在巴基斯坦启动了先天性甲状腺功能减退症筛查。到1988年4月，已筛查5000名新生儿，确诊5例先天性甲状腺功能减退症。该研究显示，甲状腺功能减退症的发病率为每1000名新生儿中有1例，约为西方发病率的4倍。
