CpG岛甲基化表型在结肠癌生存结局中的作用。
The role of the CpG island methylator phenotype on survival outcome in colon cancer.
作者信息
Kang Ki Joo, Min Byung Hoon, Ryu Kyung Ju, Kim Kyoung Mee, Chang Dong Kyung, Kim Jae J, Rhee Jong Chul, Kim Young Ho
机构信息
Department of Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
Departments of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
出版信息
Gut Liver. 2015 Mar;9(2):202-7. doi: 10.5009/gnl13352.
BACKGROUND/AIMS: CpG island methylator phenotype (CIMP)- high colorectal cancers (CRCs) have distinct clinicopathologi-cal features from their CIMP-low/negative CRC counterparts. However, controversy exists regarding the prognosis of CRC according to the CIMP status. Therefore, this study examined the prognosis of Korean patients with colon cancer according to the CIMP status.
METHODS
Among a previous cohort pop-ulation with CRC, a total of 154 patients with colon cancer who had available tissue for DNA extraction were included in the study. CIMP-high was defined as ≥3/5 methylated mark-ers using the five-marker panel (CACNA1G, IGF2, NEUROG1, RUNX3, and SOCS1).
RESULTS
CIMP-high and CIMP-low/neg-ative cancers were observed in 27 patients (17.5%) and 127 patients (82.5%), respectively. Multivariate analysis adjust-ing for age, gender, tumor location, tumor stage and CIMP and microsatellite instability (MSI) statuses indicated that CIMP-high colon cancers were associated with a significant increase in colon cancer-specific mortality (hazard ratio [HR], 3.23; 95% confidence interval [CI], 1.20 to 8.69; p=0.02). In microsatellite stable cancers, CIMP-high cancer had a poor survival outcome compared to CIMP-low/negative cancer (HR, 2.91; 95% CI, 1.02 to 8.27; p=0.04).
CONCLUSIONS
Re-gardless of the MSI status, CIMP-high cancers had poor sur-vival outcomes in Korean patients. (Gut Liver, 2015;9202-207).
背景/目的：CpG岛甲基化表型（CIMP）-高的结直肠癌（CRC）与CIMP-低/阴性的CRC在临床病理特征上有所不同。然而，关于根据CIMP状态判断CRC的预后存在争议。因此，本研究根据CIMP状态对韩国结肠癌患者的预后进行了研究。
方法
在先前的CRC队列人群中，共有154例有可用组织进行DNA提取的结肠癌患者纳入研究。使用五个标志物组合（CACNA1G、IGF2、NEUROG1、RUNX3和SOCS1）将CIMP-高定义为≥3/5个甲基化标志物。
结果
分别在27例（17.5%）和127例（82.5%）患者中观察到CIMP-高和CIMP-低/阴性癌症。对年龄、性别、肿瘤位置、肿瘤分期以及CIMP和微卫星不稳定性（MSI）状态进行多变量分析表明，CIMP-高的结肠癌与结肠癌特异性死亡率显著增加相关（风险比[HR]，3.23；95%置信区间[CI]，1.20至8.69；p = 0.02）。在微卫星稳定的癌症中，与CIMP-低/阴性癌症相比，CIMP-高的癌症生存结果较差（HR，2.91；95%CI，1.02至8.27；p = 0.04）。
结论
无论MSI状态如何，CIMP-高的癌症在韩国患者中的生存结果较差。（《胃肠肝脏病学》，2015；9：202 - 207）
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