Onoyama K, Kumagai H, Takeda K, Shimamatsu K, Fujishima M
2nd Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Nephrol Dial Transplant. 1989;4(11):966-70. doi: 10.1093/ndt/4.11.966.
Seven anaemic patients with predialysis chronic renal failure were treated with human recombinant erythropoietin. Anaemia was improved, with a 31% increase in haematocrit, but blood pressure increased in all patients with an average of 12% in systolic (P less than 0.01), 14% in diastolic (P less than 0.05) and 13% in mean blood pressure (P less than 0.05). Blood volume was significantly increased by an average of 12%. Cardiac output increased in three of seven patients, and total peripheral resistance in four. GFR, RBF and RPF were not changed but filtration fraction increased significantly (P less than 0.05). It is suggested that blood pressure elevation might be developed as a result of volume expansion, elevated cardiac output, and increased total peripheral resistance.
七名透析前慢性肾衰竭的贫血患者接受了重组人促红细胞生成素治疗。贫血状况得到改善，血细胞比容增加了31%，但所有患者的血压均升高，收缩压平均升高12%（P<0.01），舒张压平均升高14%（P<0.05），平均血压升高13%（P<0.05）。血容量平均显著增加了12%。七名患者中有三名心输出量增加，四名患者总外周阻力增加。肾小球滤过率、肾血流量和肾血浆流量未改变，但滤过分数显著增加（P<0.05）。提示血压升高可能是由于血容量扩张、心输出量增加和总外周阻力增加所致。
