在早期前列腺癌患者中，CT灌注成像与前列腺特异性抗原（PSA）及术前Gleason评分之间无显著相关性。
Integrated CT-perfusion shows no meaningful correlation with PSA and presurgical Gleason score in patients with early prostate cancer.
作者信息
Huellner Martin W, Mattei Agostino, Ross Steffen, Butea-Bocu Marius, Vosbeck Jürg, Pauli Chantal, Diebold Joachim, Seifert Burkhardt, Strobel Klaus, Veit-Haibach Patrick
机构信息
Department of Radiology and Nuclear Medicine, Lucerne Cantonal Hospital, Spitalstrasse 1, 6004 Lucerne, Switzerland.
Department of Urology, Lucerne Cantonal Hospital, Spitalstrasse 1, 6004 Lucerne, Switzerland.
出版信息
Clin Imaging. 2014 Nov-Dec;38(6):850-7. doi: 10.1016/j.clinimag.2014.07.011. Epub 2014 Aug 2.
OBJECTIVES
To analyze the correlation of computed tomography (CT) perfusion parameters blood flow (BF), blood volume (BV), and mean transit time (MTT) with presurgical prostate cancer data.
METHODS
Ninety-eight patients with biopsy-proven prostate cancer underwent a CT-perfusion scan of the prostate. MTT, BF, and BV were determined and correlated with prostate-specific antigen (PSA) level, tumor load and Gleason score of transrectal ultrasonography-guided biopsy specimens.
RESULTS
Mean BF was 41.3 ml/100 ml*min(-1), BV 5.2 ml/100 ml, MTT 8.7 s. Moderate correlations were observed between Gleason score and BF (0.35) and between PSA and BF (0.33) and BV (0.30).
CONCLUSIONS
CT-perfusion shows no valuable correlation with presurgical prostate cancer data.
目的
分析计算机断层扫描（CT）灌注参数血流量（BF）、血容量（BV）和平均通过时间（MTT）与术前前列腺癌数据的相关性。
方法
98例经活检证实为前列腺癌的患者接受了前列腺CT灌注扫描。测定MTT、BF和BV，并将其与经直肠超声引导下活检标本的前列腺特异性抗原（PSA）水平、肿瘤负荷和Gleason评分进行相关性分析。
结果
平均BF为41.3 ml/100 ml*min(-1)，BV为5.2 ml/100 ml，MTT为8.7 s。Gleason评分与BF（0.35）、PSA与BF（0.33）以及PSA与BV（0.30）之间存在中度相关性。
结论
CT灌注与术前前列腺癌数据无显著相关性。
Zotero 插件