Mahmoud Abla Sayed, Umair Ayesha, Azzeghaiby Saleh Nasser, Alqahtani Fahad Hussain, Hanouneh Salah, Tarakji Bassel
Department of Oral Maxillofacial Sciences, Alfarabi College of Dentistry Alfarabi, Kingdom of Saudi Arabia E-mail :
Asian Pac J Cancer Prev. 2014;15(16):6787-90. doi: 10.7314/apjcp.2014.15.16.6787.
The aim of this study was to evaluate cyclooxygenase-2 (COX-2) immunoreactivity in colorectal adenocarcinomas and to find correlations with different pathological features.
This study included 35 cases of colorectal carcinoma for which surgical colectomy specimens were collected. Immunohistochemical staining of COX-2 (cyclooxygenase-2) is done by using the Streptavidin-biotin technique.
This work reveals that COX-2 is positive in most cases of colorectal carcinoma and negative in normal colon tissue with statistically non significant relations between COX-2 immunostaining and different pathological features.
Our data suggest overexpression of COX-2 protein in colorectal carcinoma in contrast to normal mucosa, with a possible role in cell proliferation in carcinogenesis.
本研究旨在评估环氧化酶-2（COX-2）在结直肠癌中的免疫反应性，并找出其与不同病理特征的相关性。
本研究纳入35例结直肠癌患者，收集其手术切除的结肠标本。采用链霉亲和素-生物素技术对COX-2（环氧化酶-2）进行免疫组织化学染色。
研究表明，大多数结直肠癌病例中COX-2呈阳性，而正常结肠组织中COX-2呈阴性，COX-2免疫染色与不同病理特征之间无统计学显著相关性。
我们的数据表明，与正常黏膜相比，COX-2蛋白在结直肠癌中过度表达，可能在肿瘤发生过程中的细胞增殖中发挥作用。
