Araujo H M, Keller R P, Fellous A, Chagas C, Moura-Neto V
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Brasil.
Braz J Med Biol Res. 1989;22(7):817-20.
Tau proteins are involved in polymerization of tubulin into microtubules. They comprise a heterogeneous group of proteins that can be resolved by two-dimensional gel electrophoresis using a non-equilibrium pH gradient in the first dimension. Developmental studies show that mouse brain Tau proteins are more heterogeneous in 15-day old mice than in newborn pups or adults. Tau phosphorylation is also more heterogeneous at this stage.
tau蛋白参与微管蛋白聚合成微管的过程。它们是一组异质性蛋白质，可通过二维凝胶电泳进行分离，其中第一维采用非平衡pH梯度。发育研究表明，15日龄小鼠脑内的tau蛋白比新生幼崽或成年小鼠的更具异质性。在这个阶段，tau蛋白的磷酸化也更具异质性。
