精神分裂症患者的强化学习缺陷在长期试验后依然存在。
Reinforcement learning deficits in people with schizophrenia persist after extended trials.
作者信息
Cicero David C, Martin Elizabeth A, Becker Theresa M, Kerns John G
机构信息
Department of Psychology, University of Hawaii at Manoa, Honolulu, HI, United States.
Department of Psychology, University of California, Irvine, Irvine, CA, United States.
出版信息
Psychiatry Res. 2014 Dec 30;220(3):760-4. doi: 10.1016/j.psychres.2014.08.013. Epub 2014 Aug 15.
Previous research suggests that people with schizophrenia have difficulty learning from positive feedback and when learning needs to occur rapidly. However, they seem to have relatively intact learning from negative feedback when learning occurs gradually. Participants are typically given a limited amount of acquisition trials to learn the reward contingencies and then tested about what they learned. The current study examined whether participants with schizophrenia continue to display these deficits when given extra time to learn the contingences. Participants with schizophrenia and matched healthy controls completed the Probabilistic Selection Task, which measures positive and negative feedback learning separately. Participants with schizophrenia showed a deficit in learning from both positive feedback and negative feedback. These reward learning deficits persisted even if people with schizophrenia are given extra time (up to 10 blocks of 60 trials) to learn the reward contingencies. These results suggest that the observed deficits cannot be attributed solely to slower learning and instead reflect a specific deficit in reinforcement learning.
先前的研究表明,精神分裂症患者在从积极反馈中学习以及需要快速学习时存在困难。然而,当学习逐渐发生时,他们似乎能相对正常地从消极反馈中学习。参与者通常会进行有限次数的习得试验来学习奖励的偶然性,然后测试他们所学的内容。当前的研究考察了给予精神分裂症患者额外时间来学习这些偶然性时,他们是否仍会表现出这些缺陷。患有精神分裂症的参与者和匹配的健康对照组完成了概率选择任务,该任务分别测量积极和消极反馈学习。精神分裂症患者在从积极反馈和消极反馈中学习时均表现出缺陷。即使给予精神分裂症患者额外的时间(多达10组,每组60次试验)来学习奖励的偶然性,这些奖励学习缺陷仍然存在。这些结果表明,观察到的缺陷不能仅仅归因于学习速度较慢,而是反映了强化学习中的特定缺陷。