De Bernardo Maddalena, Capasso Luigi, Tortori Antonia, Lanza Michele, Caliendo Luisa, Rosa Nicola
Department of Medicine and Surgery, University of Salerno, Salerno, Italy.
U.O.C. Prelievo e Trapianto Cornee, Pellegrini Hospital, Naples, Italy.
Cont Lens Anterior Eye. 2014 Dec;37(6):438-41. doi: 10.1016/j.clae.2014.07.007. Epub 2014 Aug 27.
To evaluate keratoconus biomechanical changes after transepithelial corneal collagen cross linking (TE CXL) using riboflavin and ultraviolet A (UVA).
Second University of Naples, Naples, Italy.
Prospective non comparative case series study.
Patients with progressive keratoconus were examined, before and during a 6 months follow up after TE CXL, with a Pentacam, an Ocular Response Analyzer and an IOLMaster. Best corrected visual acuity (BCVA), refraction, corneal thinnest point (CTP), keratometry readings at the keratoconus apex (Kmax), axial eye length (AL), corneal volume (CV) anterior chamber volume (ACV), anterior chamber depth (ACD), corneal hysteresis (CH) and corneal resistance factor (CRF) were evaluated.
Thirty-six eyes of 36 patients with progressive keratoconus were analyzed. Six months after treatment there was a significant improvement in BCVA (p<0.01), no significant changes in refraction (p=0.57), CTP (p=0.07), Kmax (p=0.88), AL (p=0.07), CV (p=0.38), ACV (p=0.07), ACD (p=0.7), CH (p=0.1) and CRF (p=0.3).
According to our results TE CXL stabilizes most of the patients with progressive keratoconus, without affecting in negative way the corneal elasticity.
评估使用核黄素和紫外线A（UVA）进行经上皮角膜胶原交联（TE CXL）后圆锥角膜的生物力学变化。
意大利那不勒斯第二大学。
前瞻性非对照病例系列研究。
对进行性圆锥角膜患者在TE CXL前及随访6个月期间，使用Pentacam、眼反应分析仪和IOLMaster进行检查。评估最佳矫正视力（BCVA）、验光、角膜最薄点（CTP）、圆锥角膜顶点的角膜曲率读数（Kmax）、眼轴长度（AL）、角膜体积（CV）、前房体积（ACV）、前房深度（ACD）、角膜滞后（CH）和角膜阻力因子（CRF）。
分析了36例进行性圆锥角膜患者的36只眼。治疗6个月后，BCVA有显著改善（p<0.01），验光（p=0.57）、CTP（p=0.07）、Kmax（p=0.88）、AL（p=0.07）、CV（p=0.38）、ACV（p=0.07）、ACD（p=0.7）、CH（p=0.1）和CRF（p=0.3）无显著变化。
根据我们的结果，TE CXL可使大多数进行性圆锥角膜患者病情稳定，且不会对角膜弹性产生负面影响。
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