Alifa Ramón, Piñero David, Velázquez José, Alió Del Barrio Jorge L, Cavas Francisco, Alió Jorge L
Doctorate Program in Industrial Technologies, International School of Doctorate, Technical University of Cartagena, 30202 Cartagena, Spain.
Group of Optics and Visual Perception, Department of Optics, Pharmacology and Anatomy, University of Alicante, 03690 Alicante, Spain.
Diagnostics (Basel). 2020 Jun 11;10(6):397. doi: 10.3390/diagnostics10060397.
Keratoconus is an ectatic disorder that is presently considered one of the most prevalent reasons for keratoplasty. Corneal collagen crosslinking (CXL) is the only proven treatment option available that is capable of halting the progression of the disease by stabilizing the cone in 90% of cases, and by also reducing refractive error and maximal keratometry. This study assesses, by means of a 3D morphogeometric analysis procedure developed by our research team, the corneal structure changes that occur immediately after CXL treatment and during a 6 month follow-up period. A total of 19 eyes from 19 patients diagnosed with keratoconus who underwent CXL were included, and several variables derived from the morphogeometric analysis were calculated and evaluated for the pre-operative, 3 month postoperative, and 6 month postoperative states. Significant reductions were detected in central corneal thickness and corneal spherical-like root mean square (RMS) 3 months after surgery, with non-significant regression of the effect afterward. Significant reductions in the total corneal area/volume were found, with some levels of regression after 6 months in certain volumetric parameters. In conclusion, the eyes with higher values for morphogeometric parameters-posterior apex deviation (PAD), anterior minimum thickness point deviation (AMTPD), and posterior minimum thickness point deviation (PMTPD)-seemed more likely to undergo aberrometric improvement as a result of CXL surgery.
圆锥角膜是一种扩张性疾病，目前被认为是角膜移植最常见的原因之一。角膜胶原交联（CXL）是唯一经证实有效的治疗方法，90%的病例中可通过稳定圆锥形态来阻止疾病进展，还可减少屈光不正和最大角膜曲率。本研究通过我们研究团队开发的三维形态几何分析程序，评估CXL治疗后即刻以及6个月随访期内发生的角膜结构变化。共纳入19例诊断为圆锥角膜并接受CXL治疗患者的19只眼，计算并评估了术前、术后3个月和术后6个月来自形态几何分析的几个变量。术后3个月中央角膜厚度和角膜类球面均方根（RMS）显著降低，之后效果无显著消退。发现角膜总面积/体积显著降低，某些体积参数在6个月后有一定程度的消退。总之，形态几何参数——后顶点偏差（PAD）、前最小厚度点偏差（AMTPD）和后最小厚度点偏差（PMTPD）值较高的眼，似乎更有可能因CXL手术而在像差测量上得到改善。
