Dow AgroSciences LLC, 9330 Zionsville Road, Indianapolis, IN 46268, USA.
Dow AgroSciences LLC, 9330 Zionsville Road, Indianapolis, IN 46268, USA.
Drug Discov Today. 2015 Jan;20(1):7-10. doi: 10.1016/j.drudis.2014.08.010. Epub 2014 Aug 27.
Twelve drugs from four chemical classes are currently available for treatment of systemic fungal infections in humans. By contrast, more than 100 structurally distinct compounds from over 30 chemical classes have been developed as agricultural fungicides, and these fungicides target many modes of action not represented among human antifungal drugs. In this article we introduce the diverse aspects of agricultural fungicides and compare them with human antifungal drugs. We propose that the information gained from the development of agricultural fungicides can be applied to the discovery of new mechanisms of action and new antifungal agents for the management of human fungal infections.
目前有 12 种来自 4 个化学类别的药物可用于治疗系统性真菌感染。相比之下，已有超过 100 种结构不同的化合物来自 30 多个化学类别的化合物被开发为农用杀菌剂，这些杀菌剂针对许多人类抗真菌药物中未涉及的作用模式。在本文中，我们介绍了农用杀菌剂的各个方面，并将其与人类抗真菌药物进行了比较。我们提出，从农用杀菌剂的开发中获得的信息可以应用于发现新的作用机制和新的抗真菌药物，以治疗人类真菌感染。
